Month: March 2009

Can you be more specific, please?!

As well as Duncan’s point (see post below), Sherman, Molloy and co-workers, also in Proteomics (vol 9), believe that monitoring the transition of a single precursor to product ion is not specific enough to define a unique peptide anyway.  This is because several peptide precursors may have equivalent mass, or may appear to have, due…


Should we be more selective?

I hate the word ‘should’ – it always implies that there is something you have to do but you’d rather put it off.  Well, I recently came across a viewpoint article that made me think we really ‘should’ be doing more to make SRM more reliable.  This commentary, in Proteomics (vol 9: 1124-1127), suggests that…


MRM is not allowed

According to the International Union of Pure and Applied Chemistry (IUPAC), the body that makes recommendations regarding nomenclature  used in mass spectrometry, ‘Multiple Reaction Monitoring’ (MRM) is an “incorrect term” .  They suggest instead that ‘selected reaction monitoring’ (SRM) is more appropriate. This subject came up at the ASMS conference in 2008 (Denver, CO), but…